Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes.

Sci Rep · 2025 · PMC12297449 · PMID 40715462

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0.0650

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boldest claim

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did not reach statistical significancep -value = 0.065so close (0.05 < p ≤ 0.1)

Analyses of UK Biobank (UKB) and FinnGen data supported significant associations between GDM, PE, and PD, although the association for PG did not reach statistical significance ( p -value = 0.065), possibly due to limited sample size.

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marginally non-significantp -value = 0.065so close (0.05 < p ≤ 0.1)

Positive associations were detected between pregnancy complications and PD: GDM [OR 1.59, 95% CI 1.03–2.32; HR 2.32, 95% CI 2.02–2.67], PE [OR 1.54, 95% CI 1.26–1.85; HR 1.65, 95% CI 1.39–1.96] and PG [HR 2.61, 95% CI 0.79–6.42], While the association for PG was marginally non-significant ( p -value = 0.065), likely due to limited sample size, the results indicate a compelling trend that warrants further investigation.

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