Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination.

RPA foci exhibited almost similar spatiotemporal distributions in both WT and MT oocytes, with a slight trend towards accumulation at the zygotene and pachytene stages, indicating that DSBs were introduced normally and resected into ssDNA in MT oocytes (Fig. 3a ).

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The results showed a trend toward reduced germ cell numbers in MT mice at E11.5 and E18.5, though this difference was not statistically significant.

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