Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk.

In addition, it is important to note that the information identified in the work of Wang et al., the nominally significant causal relationship between a higher level of SHBG and a lower UF risk, according to the authors themselves (!) contradicts one of the main conclusions made in their work—“ the protective effect of a higher level of total testosterone on uterine leiomyoma, as higher SHBG usually means less bioactive testosterone” [ 23 ].

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