KMT2D coordinates antiviral CD4<sup>+</sup> T cell responses through opposing effects on T follicular helper and cytotoxic gene expression.

Consistent with loss of KMT2D methyltransferase activity, activated CD4 + and CD8 + T cells from KMT2D TCD mice had a highly significant reduction in H 3 K 4 Me1 compared to WT ( Figure 1D ).

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In contrast, KMT2D TCD cells trended toward an increase in clusters 4 and 5 (T H 1-like), although this did not reach statistical significance.

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