Peripheral inflammation and neurocognitive functioning in early psychosis: Specific associations of TNF-α and IL-6 with social cognition.

Eur Psychiatry · 2025 · PMC12303774 · PMID 40637145

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0750

boldest claim

The sentences

a trend toward significancep = 0.054so close (0.05 < p ≤ 0.1)

IQ showed a trend toward significance ( β = −0.034, p = 0.054), implying that lower IQ may be related to increased undermentalization.

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showed a trendp = 0.075so close (0.05 < p ≤ 0.1)

In adjusted regression models, IL-6 was significantly associated with undermentalization on the MASC task ( β = 0.28, p = 0.0337) and showed a trend-level association with slower processing speed ( β = 0.98, p = 0.075).

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