Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis.

Although reductions in glomerular leukocyte recruitment in anti-TNF-α-treated mice did not reach statistical significance ( Figures 2D–F ), the improvement in glomerular injury was associated with reduced intrarenal macrophages (% F4/80 + of CD45 + cells) and reduced cellular-mediated anti-MPO DTH footpad swelling in anti-TNF-α-treated mice ( Figures 2G–H ).

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