Deciphering gene-smoking interactions in age-related macular degeneration through cross-biobank genomic integration.

Tob Induc Dis · 2025 · PMC12306451 · PMID 40735363

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0700

boldest claim

The sentences

highly significantp<0.01actually significant

Therefore, statistical significance in interaction models was defined as p<0.05, with highly significant results at p<0.01.

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nominally significantp<0.05actually significant

Of the 21 loci, 13 were nominally significant (p<0.05) in UKBB, including one variant (rs4388642 in CFH, p=1.82×10 -17 ) reaching Bonferroni-corrected significance (Supplementary file Table S3).

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borderline significantp=0.07so close (0.05 < p ≤ 0.1)

Although the association was borderline significant in Model 2 (HR=1.05; 95% CI: 1.00–1.11, p=0.07), it was not significant in Model 3 (HR=1.04; 95% CI: 0.98–1.10, p=0.17).

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