Reevaluating anticoagulation therapy for sepsis-associated disseminated intravascular coagulation based on endothelial glycocalyx shedding quantification: a single-center, retrospective, observational pilot study.

A multinational, randomized, placebo-controlled, double-blind, phase III trial using antithrombin III and rhTM was conducted to investigate their efficacy and safety in adult patients with sepsis and coagulopathy ( 34 , 35 ); however, the absolute risk of 28-day mortality did not reach statistical significance ( 34 ).

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