CD8-positive lymphocyte infiltration as a marker of anti-tumor immune response in rectal cancer: pre- and post-neoadjuvant radiotherapy comparison.

Clin Transl Radiat Oncol · 2025 · PMC12309852 · PMID 40741211

Europe PMC DOI

hedged sentences

0.0960

closest p · 1.9× alpha

0.0960

boldest claim

The sentences

a nonsignificant trendP = 0.096so close (0.05 < p ≤ 0.1)

SCRT: 21.36, P = 0.025), favoring higher numbers in the LCRT group, as well as a nonsignificant trend towards higher pre-treatment median CD8+ lymphocyte percentage in LCRT (10 % vs 6 %, P = 0.096); however, there were no statistically significant differences between the two treatment groups in the number or percentage of CD8+ lymphocytes in post-treatment samples.

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did not reach statistical significanceno p-value reported

Although there was a numerically higher mean CD8+ count in patients achieving TRG 0–1 compared to TRG 2–3, the difference did not reach statistical significance.

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