The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization.

Although the results did not reach statistical significance, EACBE deletion was associated with a reduction in the germline transcription of these segments, including Trav17 , Trdv2-2 , Trdd2 , E δ , and Trdc , with Trdv2–2 exhibiting the most pronounced decrease ( Figure 3G ).

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