Red pulp macrophages clear parasites, while marginal metallophilic and marginal zone macrophages support CD4<sup>+</sup> T cell activation during <i>Plasmodium yoelii</i> infection.

Herein, we observed a slight trend to lower frequencies of IFNγ- and granzyme B-expressing CD4 + T cells from the CL-treated, infected group, which did not reach significance ( Figures 2G, H ).

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We note that MZMΦ and MMMΦ showed a trend towards increased frequencies, which did not reach significance in infected KO mice compared to WT mice ( Figures 7A, B ).

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