Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington's disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition.

Mol Med · 2025 · PMC12312528 · PMID 40739177

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Additionally, we observed a significant trend toward an increase in IL-1β levels in the 3-NP group compared to the CFA-only group ( t (8) = 2.464, p < 0.05; Fig. 7 C) and a non-significant downward trend compared to the Vehicle group ( t (8) = 2.232, p = 0.056).

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