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Co-expression of IL-15 and CCL21 strengthens CAR-NK cells to eliminate tumors in concert with T cells and equips them with PI3K/AKT/mTOR signal signature.

J Immunother Cancer · 2025 · PMC12314829 · PMID 40518288

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While stimulation through the CD19 CAR appeared to enhance the secretion of both cytokines, the differences did not reach statistical significance ( online supplemental figure 1B ).

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