Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats.

Nanotechnol Sci Appl · 2025 · PMC12315901 · PMID 40756009

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did not reach statistical significanceno p-value reported

While acute-phase glial activation showed limited response to intervention with FA-LNPs, Fluoro-Jade staining revealed that FA-LNP treatment did not effectively attenuate LPS-induced neurodegenerative changes, and even showed a subtle trend towards increased neurodegeneration, although this did not reach statistical significance.

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