miRNA centered regulatory networks identify FN1 and miR27b as metastatic drivers in HPV negative head and neck cancer.

Consistent with the repression of miR-27b in patients with metastasis, the mRNA levels of the five target genes were overexpressed, although LAMC1 expression did not reach statistical significance in TCGA cohort.

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However, the marginal significance observed in some associations may reflect the complex relationship between metastatic status and patient survival, potentially influenced by confounding factors such as aggressive local treatment strategies for metastatic patients 58 , 59 .

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