Association between glycemic control and hepatocellular carcinoma risk in people with type 2 diabetes, stratified by chronic hepatitis B or C infection.

Ther Adv Gastroenterol · 2025 · PMC12317228 · PMID 40756178

Europe PMC DOI

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0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

marginally non-significantp = 0.067so close (0.05 < p ≤ 0.1)

Additional Cox regression including a quadratic term (baseline HbA1c2), showing a marginally non-significant trend ( p = 0.067) suggested potential nonlinearity (data not shown).

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did not reach statistical significanceno p-value reported

In contrast, among individuals without viral hepatitis, we observed a trend of reduced HCC risk especially in those with presumed MAFLD who achieved optimal glycemic control, and although this finding did not reach statistical significance, this trend is consistent with prior studies linking high glycemic burden to HCC development in patients with nonalcoholic fatty liver disease. 34 Our results emphasize the relevance of glycemic optimization in subgroups with underlying metabolic liver disease.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.