Alterations in vaginal microbiome in women with short cervix: longitudinal study of microbial diversity and impact of vaginal progesterone treatment.

In contrast, in the longitudinal analysis of the vaginal microbiome from women with a short cervix (Figure 4b ), there was a notable decrease (although this did not reach statistical significance) in the relative abundance of L. crispatus from the first trimester (55.0%) to the second trimester (36.1%) ( P = 0.052), then a slight increase in the third trimester (to 41.2%) ( P = 0.133).

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