C-reactive Protein/Albumin Ratio as a Prognostic Indicator for Predicting Surgical Intervention in Neonates With Necrotizing Enterocolitis: A Prospective Cohort Study.

Neonates with an increasing CRP/Albumin ratio trend had a significantly higher rate of surgical intervention (89.5%) and mortality (26.3%) compared to those with a decreasing trend (8.1% surgery and 2.6% mortality) (p < 0.001).

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Although the overall association between CRP/Albumin ratio and mortality did not reach statistical significance, subgroup analyses revealed meaningful differences, with higher mortality observed in the increasing trend group than in the other subgroups.

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Importantly, our findings revealed that neonates with an increasing trend in CRP/Albumin ratio had higher rates of surgical intervention, prolonged hospital stay, and mortality, compared to those with a decreasing trend.

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