Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia.

Neurobiol Dis · 2025 · PMC12320091 · PMID 40633679

Europe PMC DOI

hedged sentence

0.0586

closest p · 1.2× alpha

0.0586

boldest claim

The sentences

a strong trendp = 0.0586so close (0.05 < p ≤ 0.1)

Interestingly, there was a strong trend toward a similar degree of nSMase2 reduction in sporadic FTLD-TDP-A ( p = 0.0586).

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