Additionally, for the 3‐month recurrence endpoint, heterogeneity and borderline significance were driven by the Jiang 2024 study; its exclusion resulted in no significant differences between PFA and RFA (Online Resource 11 ) [ 30 , 33 ]. 4.
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Pulsed-Field Ablation Versus Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis.
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In contrast, other studies including smaller proportions of very elderly patients did not reach statistical significance for these outcomes.
Regarding clinical efficacy, our analysis showed a borderline significant reduction in arrhythmia recurrence at 3 months with PFA, which might hint at more durable acute lesion formation with electroporation, as suggested by some mechanistic and redo studies [ 29 , 31 , 40 , 41 , 42 ].