Real-world analysis of strategies to prevent thrombosis and bleeding in adults with ALL treated with asparaginase.

17 The randomized, controlled PAARKA trial in the pediatric ALL population showed a trend toward a reduction in Asp-associated VTE for children receiving AT repletion vs no repletion, but there have been no randomized studies of AT prophylaxis for Asp-associated VTE in adults with ALL. 18 The nonrandomized, retrospective studies that have been performed in adults show conflicting result

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