Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients with Atrial Fibrillation and Bioprosthetic Valve Replacement: An Umbrella Review.

This outcome yielded a highly significant P value of <.00001, as shown in Figure 2 .

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The results showed a trend favoring DOACs for reduced all-cause mortality. 9 , 10 , 20 – 31 , 33 , 36 , 37 Some studies suggested comparable or superior outcomes for DOACs in reducing all-cause mortality and major bleeding compared to VKAs.

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