Low-dose dietary vorinostat increases brain histone acetylation levels and reduces oxidative stress in an Alzheimer's disease mouse model.

First, we observed significant correlations between VOR dose and AH3 level (r = 0.60, p = 0.0004) and TAC (r = 0.71, p < 0.0001) as well as moderately significant correlations with weight change (r = −0.44, p = 0.0159), H3 level (r = 0.52, p = 0.0033), HDAC activity (r = −0.39, p = 0.0324), and H 2 O 2 (r = −0.47, p = 0.0085).

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