Differential effects of β-blockers nebivolol and metoprolol on mitochondrial biogenesis and antioxidant defense in angiotensin II-induced pathology in H9c2 cardiomyoblasts.

BMC Pharmacol Toxicol · 2025 · PMC12323040 · PMID 40759985

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an increasing trendno p-value reported

However, only TFAM and NRF-1 showed a significant increase with metoprolol, while SIRT3 and PGC-1α displayed an increasing trend.

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did not reach statistical significanceno p-value reported

However, the increase observed with metoprolol did not reach statistical significance and was only a trend.

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