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Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration.

Clin Epigenetics · 2025 · PMC12323057 · PMID 40760448

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LiverClock displayed a similar correlation between EAA and MASLD, but the individual histological parameters did not reach statistical significance, while HepClock EAA and Horvath’s IEAA showed no significant correlations with MASLD (Fig. 7 A).

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