Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES.

Epigenetics · 2025 · PMC12323417 · PMID 40758856

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hedged sentences

0.0001

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp < 0.0001actually significant

Correspondingly, the trend analysis for GrimAge2Accel across SII tertiles was also highly significant ( p < 0.0001), reinforcing the positive relationship.

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did not reach statistical significancep -values > 0.05actually significant

Correlation of SII with HorvathAccel, Skin&BloodAccel, and HannumAccel As demonstrated in Table 2 , the association between the continuous SII and SII tertiles with HorvathAccel did not reach statistical significance across all three models (all p -values > 0.05).

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