Hypercholesterolemia and the role of lipid metabolism gene CES1 in immune infiltration promote central nervous system relapse in acute myeloid leukemia.

Both subgroups showed consistent trends in lipid differences between the non-CNS relapse and CNS relapse groups ( Supplementary Figures S2, S3 ), although some differences did not reach statistical significance, particularly in the APL group (likely due to the reduced number of CNS relapse cases after grouping).

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