Effects of belimumab on peripheral blood Breg cells and cytokines in childhood systemic lupus erythematosus.

With ongoing treatment, both groups showed a decreasing trend in B cell proportions, with statistically significant differences observed within each group (all P < 0.05).

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Although some primary endpoints, like SRI4, did not reach statistical significance, belimumab showed a favorable trend in disease control and a lower incidence of serious adverse events.

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