Lack of glutamate neurotransmission in melanin-concentrating hormone neurons alters mouse reproduction and metabolism in a sex-specific manner.

Biol Sex Differ · 2025 · PMC12326619 · PMID 40770666

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hedged sentences

0.0530

closest p · 1.1× alpha

0.0630

boldest claim

The sentences

showed a trendp = 0.053so close (0.05 < p ≤ 0.1)

Total daily energy intake was not different between genotypes in either sex, although males showed a trend towards reduced daily (24 h) energy intake ( p = 0.053).

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a weak trendp = 0.063so close (0.05 < p ≤ 0.1)

At 24 weeks of age, body weight of males from both genotypes remained similar ( p = 0.81), but whereas control mice exhibited increased weight gain on HFD ( p = 0.03), Pmch ΔVglut2 male mice showed only a weak trend towards increased body weight ( p = 0.063) compared to mice in regular chow diet (Fig. 6 C-D).

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