Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis.

Although body and organ weights did not differ between Apc Min/+ ‐ Hkdc1 ∆IEC and WT mice (Supplementary Figure S7 ), intestinal tumor counts in Apc Min/+ ‐ Hkdc1 ∆IEC trended lower compared to WT mice, though this did not reach statistical significance ( P = 0.102 for the small intestine and P = 0.197 for the colon (Figure 1J ).

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