Molecular profiling of rheumatoid Arthritis: Expression dynamics of hsa_circ_0092125 and <i>G6PD</i> in an integrative gene expression study.

We specifically examined their relationships with RF and anti -CCP levels; however, the findings did not reach statistical significance, indicating that these gene expressions are not strongly associated with the clinical features analyzed ( Table 4 ). 3.5 ROC curve analyses To assess the diagnostic utility of these candidate biomarkers, ROC curve analysis was performed. hsa_circ_0092125 yielded an AUC of 0.7072 (95 % CI: 0.5612–0.8532, p = 0.0120), reflecting moderate diagnostic accuracy and indicating its potential value as an adjunctive, rather than standalone, diagnostic marker for RA ( Fig. 5 C).

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