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Impact of Treatment Adjustment on the Endoscopic Prognosis of Postoperative Anastomotic Lesions in Patients With Crohn's Disease.

Clin Transl Gastroenterol · 2025 · PMC12330364 · PMID 40392253

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Although subgroup analyses demonstrated significant adjustment treatment benefits (endoscopic mucosal healing and ulcer improvement, P < 0.05) in some subgroups (no smoking patients, no perianal disease, number of biologics ≤1, no residual disease, mild anastomotic ulcers, intermediate anastomotic ulcers, and NLR ≤ 2), the interaction tests between these variables (smoking, perianal lesions, number of biologics, residual lesions, types of anastomotic ulcers, and NLR) and adjustment treatment did not reach statistical significance (all p-interaction >0.05; see Supplementary Figures 4 and 5, Supplementary Digital Content, http://links.lww.com/CTG/B315 ).

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