Loss of proton-sensing GPR4 reduces tumor progression in mouse models of colon cancer.

Differences were considered significant at a P ‐value of <0.05 (*), highly significant at a P ‐value of <0.01 (**) and very highly significant at a P ‐value of <0.001 (***). 3.

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Analysis of luciferase activity showed a trend towards decreased luminescence in Gpr4 −/− mice (Fig. 1B ).

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