Barely Significant
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A pharmacovigilance study of vortioxetine based on data from the FDA adverse event reporting system.

Sci Rep · 2025 · PMC12332032 · PMID 40775011

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a significant trendno p-value reported
Conversely, β value > 1, with the 95% CI excluding 1, reflects a wear-out failure pattern, where the risk of AEs increases over time, indicating a significant trend of rising risk with extended treatment duration.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.