PEGylated liposomal metformin overcomes pharmacokinetic barriers to trigger potent mitochondrial disruption and cell cycle arrest in hepatocellular carcinoma.

A two-way ANOVA conducted across both cell lines demonstrated a highly significant main effect of drug concentration (F(1,80) = 199.32, p < 1.99e − 23), a significant interaction between formulation and concentration (F(3,80) = 8.01, p < 9.89e − 05), and a significant main effect of formulation type (F(3,80) = 4.08, p = 0.0095), indicating that cytotoxicity is concentration-dependent and formulation-specific, with more pronounced differences observed at higher doses.

also in 82,756 other papers

The % DNA in tail reached 13.4 ± 0.4% (95% CI: 12.6–14.2, p = 0.0918, approaching significance) and tail moment 1.2 ± 0.17 (95% CI: 0.87–1.53, p = 0.0274), with the tail moment being significantly higher than the control’s 0.59 ± 0.18 (95% CI: 0.55–0.63).

also in 1,619 other papers