Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH.

Although it did not reach statistical significance, the percentage of resident macrophages increased in FFC-fed S1pr1 MKO mice, with a corresponding increase in the percent of Timd4+ and CD206+ resident macrophage subsets (Figure 4 B).

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