MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury.

This Class B profile was almost completely absent in patients with 2 copies of the MICB G406A variant allele, only 1 of 31 patients, and there was a nonsignificant trend toward reduced odds of having the Class B profile with increasing copies of the MICB G406A variant allele ( Figure 7D ; P = 0.248, P adj = 0.1).

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In support of this, a meta-analysis of COVID-19 GWAS ( 65 ) showed a trend toward reduced risk of both hospitalization and critical disease in patients with the variant allele.

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