Aberrant brain structural-functional coupling and structural/functional network topology explain developmental delays in pediatric Prader-Willi syndrome.

For the functional networks, the differences in the p values of γ and σ between the two groups were nearly significant, suggesting that the balance between integration and segregation across the brain is fragile in children with PWS. γ is the normalized expression of Lp and is a key indicator for determining whether network σ is shifted to a more regular or random state [ 26 ].

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