Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease.

Intriguingly, MFG-E8 decoration of LC axons was clearly increased compared to WT animals and even showed a trend towards an increase compared to App NL-G-F mice (Fig. 4j, k ).

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Of note, a slight trend toward a decreased responsiveness of mitral cells in App NL-G-F mice could be detected when comparing F-I relationships with and without the presence of administered NA, which might be indicative for a homoeostatic downregulation of adrenergic receptors upon decreased NA release (Supplementary Fig. 4j ).

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