Comprehensive Analysis of the Effects of Sacubitril/Valsartan According to Sex Among Patients With Heart Failure and Reduced Ejection Fraction in PARADIGM-HF.

J Am Heart Assoc · 2025 · PMC12334938 · PMID 40265590

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nominally significantno p-value reported

There was also a nominally significant interaction between sex and the effect of sacubitril/valsartan on emergency department visits, with a greater effect in women, but this was based on small numbers of events and not supported by another exploratory analysis of outpatient worsening leading to intensification of therapy.

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