Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.

5 G) included 773 genes, which is highly significant ( p = 8.5 × 10− 142 ) with a strong odds ratio of 10.27, indicating that the overlap is about 10 times more frequent than would occur by chance.

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This shortcoming reduces the statistical robustness of our mixed model analyses of IBA-1 and P2RY12 protein levels, which increases the risk of Type 1 error (and may explain why post hoc comparisons failed to reach statistical significance).

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