Trimethylamine N-Oxide Mitigates Perioperative Neurocognitive Disorders via ANXA1 Nuclear Translocation and M2 Microglial Polarization in the Hippocampus.

The levels of ANXA1 in the hippocampus of mice showed a trend of initially decreasing and then increasing across six time points after anesthesia and surgery: 6 h, 12 h, 24 h, 72 h, and 7 days.

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