Therapeutic effects of a pulsatile GnRH pump on adult male patients with congenital hypogonadotropic hypogonadism (CHH): a retrospective study.

Our results not only showed that the patients with an initial testicular volume <4 mL showed a longer time for the emergence of sperm and a lower spermatogenic recovery percentage [confirming that the testicular volume (<4 mL) was a critical factor in predicting spermatogenesis], but we also found that the age at initial treatment may affect the treatment results—implying that initiating treatment for CHH at an early age might achieve better results though we did not reach statistical significance between the two subgroups due to the small number of samples.

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