Placebo-Controlled, Randomized Double-Blind N-Of-1 Trial to Study Safety and Potential Efficacy of TJ-68 for Improving Muscle Cramps in Patients With Amyotrophic Lateral Sclerosis: A Pilot Study.

Muscle Nerve · 2025 · PMC12338019 · PMID 40545904

Europe PMC DOI

hedged sentence

0.3500

closest p · 7.0× alpha

0.3500

boldest claim

The sentences

did not reach statistical significancep = 0.35not close (p > 0.1)

Although the primary outcome measure did not reach statistical significance ( p = 0.35), several secondary measures showed significant results: MCS #1 triggering of cramps ( p = 0.01), MCS #2 cramp frequency ( p = 0.03), MCS Additional 1 change of motor behaviors ( p = 0.02), and CGIC assessed by the evaluator ( p = 0.009).

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