<i>Sesn-1</i> is required for lifespan extension during caloric deprivation in <i>C. elegans</i> through inhibition of mTORC1 and activation of autophagy.

Aging (Albany NY) · 2025 · PMC12339033 · PMID 40728520

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did not reach statistical significanceno p-value reported

The contribution of sesn-1 to the FOXO pathway and lifespan extension in eat-2(ad1116) nematodes was appreciable but did not reach statistical significance ( Figure 6A – 6D and Table 2 ).

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&lt;i&gt;Sesn-1&lt;/i&gt; is required for lifespan extension during caloric deprivation in &lt;i&gt;C. elegans&lt;/i&gt; through inhibition of mTORC1 and activation of autophagy.

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<i>Sesn-1</i> is required for lifespan extension during caloric deprivation in <i>C. elegans</i> through inhibition of mTORC1 and activation of autophagy.