Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia.

In other sensitivity analyses, we observed the effect of metabolites on cognitive function (3MSE) to be modified by age, but in stratification analyses, the significant associations were no longer nominally significant, although the attenuation appeared attributable to the smaller sample size within each age group ( Supplementary Table 8 ).

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