showed a trendp < 0.05
These finding suggest that IPCRL1 knockdown inhibits myocardial apoptosis in mice following MIRI. Knockdown of IPCRL1 Modulates miR-185-3p and JIP3 to Participate in the JNK Pathway After MIRI, the expression levels of JIP3, phosphorylation levels of JNK, and the downstream pathway-associated protein c-Jun increased, but these protein levels showed a trend toward restoration following IPCRL1 knockdown (p < 0.05, Figure 2C and D ). qRT-PCR results revealed a significant increase in JIP3 mRNA expression and a significant decrease in miR-185-3p mRNA expression in the MIRI and MIRI+NC groups compared with the Sham group (p < 0.05, Figure 2E ).