An upgraded nuclease prime editor platform enables high-efficiency singled or multiplexed knock-in/knockout of genes in mouse and sheep zygotes.

Protein Cell · 2025 · PMC12342182 · PMID 39832212

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With both the full-length and SPLΔRH-tag uPEn, pegRNA-M-Ins#1 showed a trend of being relatively more active between the two pegRNAs for introducing accurate edits and indels ( Fig. 1D ).

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