Oestrogen replacement combined with resistance exercise in older women with knee osteoarthritis: a randomised, double-blind, placebo-controlled clinical trial.

Furthermore, when participants were stratified into two groups based on the median of the weekly average pain VRS, as shown in Appendix 8 in the supplementary data, the ERT group in the high-pain category exhibited a tendency towards a greater improvement in CS-30, although the difference did not reach statistical significance [coefficient: 1.55 (95% CI: −0.16, 3.27), P = .07].

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