Although the quadratic regression between the connectivity from the right putamen to the left caudate and motor score did not reach significance (Figure 4D2 , R 2 = 0.17, p = 0.059), it showed a trend, indicating a possible nonlinear association. 4 Discussion Following the definition of the bilateral caudate nucleus, putamen, and motor cortex related to HD clinical features (especially motor symptoms), this study further revealed that the spontaneous resting‐state activity of these brain regions correlated with their respective structural atrophy, showing negative correlations in the bilateral caudate nucleus and positive correlations in the bilateral putamen.
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Stage-Dependent Inhibitory Connectivity in Striatal-Motor Circuit in Huntington's Disease.
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